Difficulties with BoNT use in ophthalmology arise as a result of toxin diffusion or inadvertent placement in the adjacent muscles. Ptosis in the eyelid is the most typical complication of BoNT treatment of strabismus and blepharospasms.23 Even though this influence is nearly always short term and self-resolving, apraclonidine 0.five% (Iopidine) or